5 Amino 1MQ - powering up the Mitochondria.
5-Amino-1Methyline Quinuclidinone (5 Amino 1 MQ)
5-Amino-1MQ is a naturally occurring peptide (or small molecule) which allows cells to suppress overactive nicotinamide N-methyltransferase (NNMT). With age, and many disease states, over expression of the NNMT causes falling NAD+ levels in mitochondria and cells. 5amino1MQ is an emerging peptide that enhances mitochondrial function by inhibiting the enzyme NNMT. This action helps maintain NAD+ levels, which are critical for energy production, DNA repair, and overall cellular health. By improving mitochondrial efficiency and reducing oxidative stress, 5-Amino-1MQ can slow down processes associated with cellular ageing, including senescence and stem cell exhaustion. 5amino1MQ also appears to stabilise and reactivate P53, a potent tumour suppressing gene, that when inactive or damaged promotes cancer. In summary 5A1MQ causes cells to produce more energy, burn more fat stores to energy, protect DNA, activate tumour suppressing genes and enhance cellular NAD+ levels.
5-Amino-1MQ holds promise for addressing mitochondrial dysfunction, a key driver of ageing and chronic diseases, and improving overall cellular metabolism.
Preclinical studies indicate that 5-Amino-1MQ is well-tolerated with no significant side effects in animal models. Human clinical trials are still in early stages, but initial data suggest a favourable safety profile. More research is needed to confirm long-term safety and efficacy, and users should consider short 3-month cycles to avoid unknown long term effects of its use.
5-Amino-1MQ may be suitable for individuals over age 40 with declining NAD+ levels experiencing obesity, metabolic dysfunction, fatigue, cognitive decline, or other signs of mitochondrial dysfunction. It is particularly useful for those seeking to address energy deficits, reduce oxidative stress, and enhance mitochondrial health.
References:
Neelakantan, H. Et Al, Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice, Biochemical Pharmacology, Volume 147, 2018, ISSN 0006-2952
https://doi.org/10.1016/j.bcp.2017.11.007
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Degtjarik, O., Golovenko, D., Diskin-Posner, Y. et al. Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun 12, 7057 (2021).
https://doi.org/10.1038/s41467-021-27142-6
Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes Jie-Ru Liu Et Al July 2021
https://doi.org/10.1155/2021/9924314
Mechanisms and inhibitors of nicotinamide N-methyltransferase, Iredia D Iyama, Rong Huana, RSC Medicinal Chemistry, Issue 8, 2021.
https://www.amazon.com/dp/B0DJ5TMPJL?binding=kindle_edition&ref=dbs_dp_sirpi
Copyright Dr Christopher Maclay 2024. All rights reserved. This article does not represent medical advice and should not be construed to do so.
Copyright Dr Christopher Maclay 2024. All rights reserved.
Disclaimer: This information is for educational purposes only, it does not constitute medical advice. Please consult with your health care practitioner for personalised medical advice.