….Animal and early human studies suggest NAD+ restoration can improve metabolism, reduce neurodegeneration, and enhance cardiovascular health. Clinical trials are ongoing to explore NAD+ precursors' effects on aging, chronic diseases, and overall healthspan........…

….gut flora is indispensable for our health and survival. Many essential substances, like certain vitamins, can only be produced by these microorganisms. This also explains why some chemicals, deemed harmless to humans because they don’t target our proteins, can still profoundly harm us by disrupting the gut flora. These microorganisms interact with dietary information, signalling our immune and neurological systems in response........…

….Guidelines are typically built on evidence from studies published in peer-reviewed journals, and these studies are overwhelmingly funded by pharmaceutical companies. Since the approval process prioritises interventions that fit the pharmaceutical model—patentable, profitable, and quantifiable—these therapies dominate the body of evidence.......…

….But chronic disease is different. It results from years and even decades of persisting low level cellular stress and dysfunction. By the time the disease emerges the cellular balancing processes, known as homeostasis, are broken.......…

….Many nations are on the brink of demographic collapse. Low birth rates have led to two severe challenges: a growing proportion of over-65s, often retired and on pensions, and a shrinking total population, with deaths dramatically exceeding births......…

…BPC-157 is a fragment of a naturally occurring gastrointestinal peptide with multiple powerful healing mechanisms….. often used for injury recovery, chronic pain and inflammation and to assist with gastrointestinal disorders and the wear and tear of ageing.....…

…5A1MQ causes cells to produce more energy, burn more fat stores to energy, protect DNA, activate tumour suppressing genes and enhance cellular NAD+ levels....…

…Aged cells and tissues  are not bathed in these messages. The absence of these peptide messengers, combined with the inevitable accumulation of errors and damage from a life well lived, cause different patterns of gene expression. Faulty or unbalanced production of the proteome, errors in post ribosome processing with vitamins minerals glycans and lipids, resulting in lower, less functional levels of metabolic and structural proteins...…

… Human chemical engineering has allowed humans to overcome seemingly impossible challenges. Since the industrial revolution it is estimated that over 350,000 ‘de novo chemicals’ have been registered globally. This is a 50 fold increase since 1950, and is projected to triple again by 2050. ...…..

…Throughout my career, I came to see the limitations of the traditional medical model in addressing the chronic disease epidemic that affects so many. We are managing chronic illness, yes, but are we truly helping people thrive? I grew convinced that the healthcare system was missing a vital opportunity….. This reactive model left little room for the proactive strategies that I believed could help many people avoid illness altogether..…

…The truth is people make choices based on the environments in which they live. The structure of our diets, daily routines, and activities is not a product of mere willpower but is heavily influenced by the reality of the world we live in and is certainly worsened by socio-economic conditions and environmental factors. People naturally respond to the world around them, an environment that is increasingly shaped by factors beyond their control..…

… Glycine is essential for several critical metabolic processes, including the synthesis of glutathione, creatine, and bile salts, with these processes alone requiring approximately 3 grams daily ……. Furthermore, glycine assists in detoxification processes like the removal of salicylates, and it supports collagen turnover, which relies heavily on glycine for structure and stability...…..

…Humanity should be healthier than ever. Today, we have greater access to food, clean water, shelter, and healthcare than any previous generation. Deaths from war, infectious diseases, and physical violence have declined significantly, thanks to advances in medicine, public health, and infrastructure. … Bur we are not.…

… this genetic code is the same in every cell of our body, aside from some minor mutations and reproductive cells. However, …… why does an intestinal cell look and function so differently from a neuron or a fat cell? The answer lies …….Each cell type requires certain segments of the genetic code to be active, producing only the specific proteins necessary to adopt its unique identity and perform its specific functions..…..

…One of the undeniable results of the publication of the Hallmarks of Ageing was providing a focus for research and therapy on the mechanisms of ageing. The science of anti-aging is evolving quickly, with research highlighting key biological targets that slow or even reverse aspects of the aging process. Here, we look at the top seven targets for anti-aging interventions as it currently stands.

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… "Food-like products" refer to highly processed foods created to resemble natural foods but not found in nature themselves. They are the norm nowadays. They are designed to provide convenience, flavour, and often an extended shelf life, appealing to the busy lifestyles …….. While they may look, feel, and sometimes taste like their natural counterparts, these products lack the fundamental characteristics and nutritional profile of whole foods..…..

…Functional medicine largely avoids the bias in orthodox medicine towards costly chronic disease ‘management’ and the acute care model. This allows functional medicine practitioners to utilise a much broader base of published biological science for their patients.…..

…The ultimate impact of regulatory capture in medicine is a healthcare system that prioritizes profit over patients. Treatment costs rise, preventive care is sidelined, and public trust in healthcare systems diminishes.…..

…A key trigger for immune senescence is age-related involution of the thymus, a small gland located in the anterior chest cavity. ……As a result, the immune system becomes hyperactive yet less efficient, diminishing its ability to perform critical functions such as immune surveillance—the early detection of tumors and infections—and the targeted removal of specific threats.…..

…Measuring biological age regularly—ideally every two years—creates a valuable feedback loop that is crucial for tracking your progress and refining your anti-aging strategy. ………validating the effectiveness of dietary, lifestyle, and therapeutic changes. Incorporating biological age measurements into your health plan not only provides motivation but also offers concrete evidence to keep you committed to your aging well goals.…..