…Curcumin, the active compound in turmeric (Curcuma longa), has gained considerable attention as a potent anti-aging intervention. ……….curcumin has been extensively studied for its potential to reduce age-related illness and mortality. … long history of use in traditional medicine and an increasing body of scientific evidence, curcumin appears to be a promising tool for promoting healthy aging..…..

…The crux of the matter is: will individuals drive the change towards defeating ageing, or will public health priorities and budgetary necessities prevail? The path forward is likely to be a blend of both, but it will require bold leadership from both the public health sector and the healthcare industry to align incentives and foster an environment where proactive ageing interventions are not only accepted but encouraged..…..

…The Circadian Rhythm is an essential biological characteristic of almost all life. …... Research indicates a noteworthy correlation between rosacea and sleep quality. A pivotal study involving 608 rosacea patients revealed……….. a clear relationship between the severity of rosacea and sleep disturbances.…..

…the role of mitochondria in aging and chronic disease opens new avenues for therapeutic interventions aimed at enhancing mitochondrial function. Strategies that promote mitochondrial health, such as lifestyle modifications, caloric restriction, and pharmacological agents targeting mitochondrial pathways, may offer potential for mitigating the effects of aging and improving healthspan…..

… Contrary to common assumptions, chronic diseases………… are not limited to wealthier nations. In fact, the World Health Organization (WHO) estimates that ‘over 85% of premature deaths due to noncommunicable diseases (NCDs)’ now occur in low- and middle-income countries. These diseases often strike earlier in life, and the cost of managing them places enormous strain on healthcare systems…..

… the discourse surrounding preventive health interventions, lifestyle is often promoted as the cornerstone of health and well-being - when this fails then medicine can intervene to manage chronic disease. I think this dichotomy is both false and harmful. This perspective tends to overlook two crucial facts…..

… The situation is particularly bleak as aging populations—people living longer but often sicker—experience rising multi-morbidity, where individuals suffer from multiple chronic conditions simultaneously. The toll on global health systems is staggering, and the costs continue to climb…..

… Senescent cells are damaged or aged cells that have stopped dividing but remain metabolically active. Recent studies suggest they may in fact be more metabolic active than normal cells. Rather than dying through the normal process of apoptosis (programmed cell death), these cells persist in the body, releasing harmful inflammatory signals and contributing to tissue dysfunction…..

...Chronic diseases, including heart disease, diabetes, cancer, and respiratory illnesses, are now the leading cause of death globally, accounting for over 70% of all deaths each year.  .....

...CMV infection exacerbates immune dysregulation, creating an environment that is ripe for other age-related conditions, including cancer, frailty, and cardiovascular disease. .....

...anti-aging, this isn’t just about looking younger. It’s about living longer and healthier, with science on our side.....

…….medicine almost completely ignores the primary cause and risk factor for chronic disease—aging……

….as we age beyond this point, cellular senescence, which once served to protect us, begins to have detrimental effects on our bodies. This phenomenon is explained by the evolutionary theory of antagonistic pleiotropy….

"inflammaging."…… chronic, low-grade inflammation associated with aging, …………. the gradual deterioration of the immune system that occurs with age, and it stands as a major risk factor for age-related diseases…..

…it is becoming apparent that the treatment of aging……..will involve the gentle realignment of cellular metabolism …… enable(ing) cells and their metabolic processes to function as designed, but at a more efficient, 'youthful' level

‘..ageing of the immune system reduces its ability to defend the body …(from) …. the causes of general frailty and the Age Related Diseases… ‘

‘small amino acid chains which act as messengers between cells and tissues…’

‘AHPRA and the TGA refer disapprovingly to ‘anti-ageing and performance enhancing public’…

Ageing itself requires treatment.