Inflammaging: Driving Age-Related Disease.

As we age, our bodies undergo various changes, one of the most significant being a characteristic inflammatory state known as "inflammaging." This term describes the chronic, low-grade inflammation associated with aging, marked by high levels of pro-inflammatory markers. Inflammaging is closely linked to immunosenescence, the gradual deterioration of the immune system that occurs with age, and it stands as a major risk factor for age-related diseases.

Several key factors contribute to immune senescence, including thymic involution, imbalances in the ratio of naive to memory cells, dysregulated metabolism, and epigenetic alterations. These features collectively impair the immune system's functionality, making the body more susceptible to infections, chronic diseases, and other health issues commonly seen in older adults.

Emerging research suggests that inflammaging is a central driver of many symptoms and diseases associated with aging. By targeting inflammaging, anti-aging therapies can potentially reduce or even reverse biological age. This, in turn, could alleviate symptoms of aging and lower the risk of developing age-related diseases.

In conclusion, addressing inflammaging through targeted treatments could revolutionize our approach to aging and improve quality of life for older individuals. By focusing on this inflammatory state, we have the potential to mitigate the adverse effects of aging and promote healthier, longer lives.

Disclaimer: This information is for educational purposes only, it does not constitute medical advice. Please consult with your health care practitioner for personalised medical advice.